P-200: Frequency of Heterochromatin Polymorphisms in Couples with Recurrent Abortions in Patients Refer to IVF Clinic of Yazd

Background: Recurrent pregnancy loss (RPL) is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of heterochromatin polymorphism in couples with recurrent miscarriages compared with couples without miscarriages. Materials and Methods: Over a 3 year period, we made a study of the diagnostic significance of heterochromatic variants in 467couples with a history of recurrent abortions and a control group of 189 couples who referred for investigation rather than abortion or diseases. Results: The results indicated significant increases of heterochromatin polymorphic variants in couples with RPL compared with couples without RPL (12.2% vs. 7.3%) p=0.0. Conclusion: Most often, chromosomes vary in size and position of heterochromatin in 1qh, 9qh, and 16qh regions. Although inherited variants have been reported not to be associated with any risk for phenotypic abnormalities, chromosomal heteromorphisms have been found to have a higher frequency relative to the normal population and have been regarded as abnormalities in some studies. Potential epigenetic, genetic, and chromosomal modifications could be associated with certain complex disorders such as infertility and bad obstetric history.